(P14) Prevalence and risk factors for depression in persons living with HIV in Norway


Lise Sørsvang¹, Bente Magny Bergersen¹, Synne Jenum¹.


¹Department of Infectious Diseases, Oslo University Hospital, Ullevål, 0424 Oslo, Norway.


In Norway, persons living with human deficiency virus (PLHIV) have legal right to mental health care free of charge. Despite this, data on the prevalence of mental health conditions in PLHIV are lacking, thus warranted. Caring for the largest PLHIV cohort in Norway, we therefore targeted depression, one of the most common mental disorders, with regard to prevalence and risk factors.

We conducted an observational cross-sectional study of consenting PLHIV aged ≥18 years attending their yearly control at the Department of Infectious Diseases, Oslo University Hospital. Data was obtained by structured interview, the Beck Depression Inventory, version II (BDI-II) and our HIV-registery (key-data entered longitudinally from diagnosis and throughout follow-up/treatment).

Of 486 PLHIV, 397(82 %) were included. Moderate-severe depression (BDI≥15) was observed in 76 (19 %). When adjusted for other factors, the likelihood for depression was increased in PLHIV originating from Asia/Latin-America (OR 2.9, 95 % KI 1.4-6.0), diagnosed prior to protease inhibitor (PI) based anti-retroviral (ART) regimen (OR 3.2, 95 % KI 1.1-7.9), municipal housing (OR 4.0, 95 % KI 1.6-10.3) and use of drugs except alcohol (OR 2.3, 95 % KI 1.2-4.3), but interestingly reduced in PLHIV with a non-nukleosid revers-transcriptase- inhibitor (NNRTI) based ART (OR 0,5, 95 % KI 0,2-0,9).

Every fifth PLHIV had depression suggesting screening in PLHIV, eventually targeted when certain risk factor(s) are present. The association between depression and NNRTI-based ART warrants further studies.

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